People with MTHFR variants often notice patterns related to methylation, detox, and neurotransmitter support. Symptoms vary, but commonly include:
Most Reported Symptoms
- Fatigue or low energy
- Anxiety or stress sensitivity
- Brain fog or poor focus
- Histamine intolerance
- Mood fluctuations
- Trouble detoxing
- Sensitivity to supplements
- Adverse reaction to synthetic folic acid
- Headaches or migraines
Why These Symptoms Happen
Most symptoms link back to:
- Reduced methylation efficiency
- Folate processing issues
- Low neurotransmitter production
- Homocysteine imbalances
- Difficulty breaking down histamines
- Nutrient deficiencies
What You Can Do
Symptoms improve for many people with:
- Folinic acid instead of folic acid
- Magnesium + B-vitamin support
- Low-histamine strategies
- Clean, nutrient-dense foods
- Balanced methylation supplements
Learn more in our Treatment Options page ➜