Practical MTHFR Treatment & Support Options
There is no one-size-fits-all solution—but there are well-researched approaches that support methylation, nervous-system balance, and overall wellness.
1. Folinic Acid (NOT Methylfolate)
Many people with MTHFR do better with folinic acid, a gentler precursor to methylated folate.
It supports methylation without over-stimulating the system.
2. Magnesium (Glycinate Recommended)
Magnesium supports over 300 biochemical processes and is vital for methylation, mood balance, and relaxation.
3. B-Complex Without Folic Acid
Choose formulas free of folic acid and heavy methyl donors.
Look for non-folic-acid, low-dose B vitamins.
4. Electrolyte Support
People with MTHFR often experience dehydration or low mineral balance, affecting energy, mood, and detox function.
5. Low-Histamine Vitamins
Histamine intolerance is more common in the MTHFR community.
Look for products with:
- No fermented ingredients
- No folic acid
- Clean, hypoallergenic formulas
6. Lifestyle & Diet Support
Treatment also includes:
- Protein + leafy greens
- Low histamine where needed
- Stress reduction
- Proper sleep
- Avoiding synthetic folic acid
Always Start Low + Go Slow
People with MTHFR are often more sensitive to supplements.
Start with low doses and increase gradually as tolerated.