Understanding the MTHFR Gene, Explained Simply

The MTHFR gene plays a key role in how your body processes folate, methylates nutrients, and produces things like neurotransmitters, energy, and detox compounds. When you have a common MTHFR variant—such as A1298C or C677T—your methylation pathway may function less efficiently.

The MTHFR Gene’s Main Job

The MTHFR gene helps convert folate into its usable form: 5-MTHF.
This process supports:

Neurotransmitter balance
Energy production
Detoxification
Healthy homocysteine levels
Hormone metabolism

The Common Variants

A1298C — typically affects neurotransmitter + mood pathways
C677T — more often affects homocysteine + vascular pathways
Compound Heterozygous — one of each

These variants are extremely common and are not diseases—just differences in processing efficiency.

Does an MTHFR Variant Mean You’re Unhealthy?

No.
It simply means your methylation pathway may need extra nutritional support.

This site is designed to help you understand what that support looks like.

Next Step

Learn the most common MTHFR symptoms here ➜